Cannabis oil is often offered to people suffering from chronic pain, inflammation and occasional pain relief. This is why people who have been diagnosed with cancer turn to products related to cannabis, including cannabis oil, when they need relief from the pain of chemotherapy or the disease itself.

Treatment of epileptic seizures

The effects of cannabis oil, especially cannabinoids such as THC, help control seizures by connecting brain cells responsible for regulation of relaxation and body control, so cannabis oil helps to ease the intensity and frequency of seizures.

Against Alzheimer’s disease

Using cannabis oil may slow the progression of Alzheimer’s disease. THC, the active chemical in cannabis oil, slows the formation of amyloid plaque by blocking the enzyme in their brain. Amyloid emissions can kill a brain cell and ultimately cause Alzheimer’s disease.

Relief from anxiety and stress

One of the most common uses of cannabis oil is to relieve anxiety and tension. The natural compounds found in cannabis oil are effective for releasing the brain, releasing the pleasure hormone, reducing the stress that gives the person a sense of relaxation.

Inflammatory bowel disease

Studies show that one of the properties of cannabis oil is the ability to help patients with inflammatory bowel disease such as ulcerative colitis and Crohn’s disease. The chemicals THC and CBD interact with the cells of the body, which plays an important role in the body’s immune responses to the intestines. THC helps the body produce enzymes that in turn help reduce intestinal permeability, which prevents bacteria from entering the cannabinoids. Cannabinoids can block germs and actually protect the intestines from bacteria that cause inflammation.

Sleep Improvement

If you suffer from constant anxiety at night, or suffer from insomnia or struggle towards a restful, uninterrupted sleep, then cannabis oil may be the solution for you. Cannabis oil works by relaxing the brain and body, and is able to lower energy levels, lower our heart rate and clean our minds to allow a long and calm sleep.

Improves heart health

Cannabis oil can help improve heart health by balancing the negative oils in the blood system. In addition, the oil can stimulate antioxidant processes and for example maximize the health of the cardiovascular system and regulate the excess cholesterol in the blood.

Vomiting and multiple sclerosis pain

One of the health benefits of cannabis oil includes the relief of pain symptoms from multiple sclerosis. The THC in cannabis oil binds to receptors in nerves and muscles to relieve pain. There are also studies that suggest that THC helps in controlling muscle spasms.

Innovations

It is a well-known fact that those who consumed cannabis in any form are aware of increased appetite. However, using cannabis oil can help you regulate your appetite and encourage hunger. At the same time, it can stimulate the digestive system in order to operate at a normal level.

Relief of Arthritis

The health benefits of cannabis oil in relation to rheumatoid arthritis include promoting sleep, reducing inflammation, and relieving pain. These effects of cannabis oil can help ease the pain and discomfort of arthritis sufferers.

Reducing glaucoma

For eye health, cannabis oil has been associated with decreased glaucoma and the prevention of molecular degeneration. Eye health is one of the main reasons why people turn to cannabis oil. Cannabis oil has been documented in many studies as lowering the glaucoma symptom because of the active substances that break down the accumulated substances in our eye, creating the green color in the eyes of those with glaucoma.

Cure for PTSD

The cannabinoids, similar to THC, contribute to the health benefits of cannabis oil. Cannabinoids help regulate the system that causes anxiety and fear in the brain and body. This specific use of cannabis oil was discovered after extensive research by many armies, such as the Israel Defense Forces, to provide a cure for sufferers of PTSD or its full name Post-Traumatic Stress Disorder

Protects the brain after stroke

Studies show that cannabis oil can help protect the brain from the damage caused by stroke. This is done by reducing the size of the area damaged by the stroke. There is a study that showed neuro-efficient effects of cannabis that protects the brain in the case of other traumatic events, such as concussion. This protection is a product of the properties of the active substances in cannabis oil, which create protection or encourage / aim the protection of the body on the brain.

Fighting cancer

Early studies have shown that the active ingredients in cannabis oil can reduce the size of the tumor and affect cancer, which means that the oil eases the presence of cancer for those suffering from the disease or in other words reduces the tumor and sometimes causes it to disappear.
Cannabis oil has several virtues against cancer, such as the ability of the active ingredient CBD to prevent cancerous cells and other blood vessels in our bodies in order to receive nutrition and continue to grow and harm our bodies. The amount of research information in this field is enormous because of the many successes that cannabis has gained in this field.

Dr. Juan Jose Marugan of National Institutes of Health (NIH) and of National Center for Translational Science Promotion (NCATS), together with his colleagues, are committed to changing this situation. With concerted efforts from other partners, they discovered a small molecule drug called metarrestin that showed inhibition of tumor metastasis in a variety of solid tumor models. Currently, they are pushing this research compound into clinical trials, especially for the treatment of pancreatic cancer. NCATS, where Dr. Marugan works, is dedicated to solving the “pain point” in translational research and improving the efficiency of translating breakthrough research into patient-benefit therapy.

Cancer metastasis – a complex and unclarified process

Cancer metastasis is a complex multi-step process. Initially, cancer cells become invasive, breaking through the barrier formed by epithelial tissue and invading into the blood vessels. After the blood circulation has moved to other parts of the body, they also need to leave the blood circulation and invade into the extravasation. Cancer metastasis does not occur in all tissues. Previous studies have shown that the environment of specific tissues in the human body is more conducive to the survival and colonization of metastatic cancer cells. The environment in which these metastatic cancer cells are suitable for survival is called pre-metastatic niches. Cancer cells that survived the pre-metastatic habitat may be lurking for a long time, and then stimulated by specific factors, the cancer cells expand and become metastatic colonization.

Since the first step in the metastasis of cancer cells is to become invasive, targeting cancer transfer has become one of the focuses of scientists. Studies have shown that intrinsic changes in a variety of tumor cells can lead to their invasive enhancement, including epithelial-mesenchymal transition (EMT), protease production and migration capacity.

However, due to the genetic instability of metastatic cancer cells, there may be no dominant signaling pathway controlling cancer metastasis in most cancer types. Our understanding of cancer metastasis is far from complete. Dr. Marugan said, “We know some of the mechanisms involved in the process of epithelial mesenchymal transition and the basic receptors and factors associated with this process. However, this knowledge is not sufficient to provide a panoramic view for developing targeted cancer metastasis.”

Another way to find new therapeutic molecules using phenotypic screening

Since it is not possible to develop drugs for specific molecular targets, Dr. Marugan’s team decided to use phenotypic screens to identify drugs that can affect the aggressiveness of cancer cells. They found that there is a structure called a perinucleolar compartment (PNC) in highly evolved cancer cells. PNC is a subnuclear body that is attached to the nucleolus of the cell. None of the early cancer cells have PNC, but a large proportion of cancer cells in metastasis have PNC, while in metastatic cancer cells, 100% of cells have PNC.

So, Dr. Marugan’s team conducted a high-throughput screening to find small molecules that could break PNC but not kill cells. They discovered that a small molecule compound, later called metarrestin, is very effective in dissolving PNC in solid tumors. So what effect does it have on cancer metastasis?

In a mouse model of cancer in mice, researchers found that if the tumor in the animal has not metastasized, metarrestin can prevent metastasis and significantly improve the survival of the animal. If metastasis has begun, metarrestin can reduce the number of metastases and extend the lifespan of animals.

In 2018, Dr. Marugan’s team published a study on metarrestin at Science Translational Medicine. Further studies have found a target for metarrestin, which originally binds to a protein called eEF1A2 and controls the function of RNA polymerase 1 (Pol 1). Pol 1 is essential for the synthesis of ribosomal RNA. Therefore, in cancer cells, eEF1A2 can help improve the biosynthesis of ribosomes, which is important for the rapid proliferation, division and evolution of cells. Metarrestin blocks the production of new ribosomes in highly evolved cancer cells by blocking eEF1A2.

Specially targeting for the treatment of pancreatic cancer

Dr. Marugan said that the current preclinical trials on metarrestin have been completed and the IND application will be submitted to the FDA. The emergence of this drug candidate is the result of collaboration among multiple research institutions. The original idea of using PNC for phenotypic screening came from Professor Sui Huang of Northwestern University. Kansas University’s Specialized Chemistry Center helped with medical chemistry research. The National Translational Science Promotion Center conducted preclinical development work, including GMP expansion, toxicology research and formulation. They will also work with the National Cancer Institute (NCI) on Phase 1 and Phase 2 clinical trials.

The National Institutes of Health (NIH) has patented metarrestin, and Dr. Marugan plans to push this research into phase 2 clinical trials and then work with pharmaceutical companies to obtain FDA approval.

Although metarrestin has produced excellent results in animal models of metastatic prostate cancer and breast cancer, Dr. Marugan said that they will mainly develop metarrestin for pancreatic cancer. Pancreatic cancer is the most terrible cancer because of high mortality. 90% of patients cannot survive for one year after diagnosis. What’ worse, for pancreatic cancer, there is almost no treatment option.

At the same time, Dr. Marugan is also exploring metarrestin-based combination therapies and early diagnosis of pancreatic cancer biomarkers in an effort to treat it more effectively at an earlier stage of cancer.

Literally, stress is no more an alien word to the new generation and is saliently killing from professionals to housewives while children doing their elementary schools are not out of the race. Rash, competition, and panic to chase and attain certain objectives are among the key causes of the scary mental condition. As per medical science, when stress triggers interfering with someone having the physical stability to live a normal life in the long term, it becomes unsafe and dangerous for him/her. You should remember that the longer the anxiety lasts with you, it would be that much worse for your whole being resulting in hypertension, fatigue, inability to concentrate and more. This is where, enrolling you as a member online and attending retreat centers in Arizona is the superlative option for you for having a break from the noisy, intensely competitive fast-paced world. How does the community help you?

Effective concentration

Let you have the opportunity to get rid of constant assault of media updates, phone calls, and emails and thereby nourish you to enhance your level of concentration. Thereby joining a renowned spiritual retreat centers in Arizona enables you to access the opportunity and reorganize the knowledge unprofessed in your and let you focus on things with a new perspective as well allowing to get clarity of your old wrong beliefs.

Change your lifestyle

There is no denying that most of us are habituated to smoking, consuming alcohol and fast foods while a large percentage already suffering from obesity, high blood sugar or hypertension are choosing crash diet courses and different workouts as they’ve heard from their buddy. Both approaches are wrong. You can come to know all these as you reach meditation retreat centers in Arizona and observe the wonderful changes in forming good habits that are under our control. By following healthy routines for body, mind, and soul, as we’re taught by the experts, we can effectively change our lifestyle and gain good habits naturally.

Be a great listener

Most of us prefer speaking rather than listening. Equally, we are deprived of listing to our souls. Listen to your own necessities with retreat centers in Arizona that helps you address many problems that you face today. After reaching the retreat center you can come across thousands of likeminded there whose interest in wellness is compatible with you. Having workouts, joining discussion sessions with learned experts and philosophers while attending silent meditation in groups offers you a different experience to look back to your shortcomings and evaluate your wrong ideas enabling you to easily incorporate them into your life. You come back to your workplace with a new vision and begin your work with fullest energy.

Learn to accept and thrive faster

Typically, the majority of us when facing any unexpected situation, typically we lose our mental balance and eventually unable to deal with those obstacles efficiently. Being egoistic stops us to reach higher positions and thus makes us failure in different areas. The retreat centers in Arizona serves as our ‘Reset’ button and offer us the great qualities of admitting our mistakes and learn from them and thus go for more challenging endeavors. This helps us thrive and lead.

Using a cold therapy unit is the most efficient way to deliver cold therapy. It a device especially designed to deliver freezing temperatures over orthopedic injuries for the speedy recovery of patients.There are various benefits of using a cold therapy unit to administer cold therapy as opposed to rudimentary methods such as ice packs or frozen vegetable bags.Cold Therapy Unit – ComponentsA cold therapy unit consists of several components such as a tank, pump, healing pad etc. To use the machine, you need to fill the tank with ice and water. The machine comes equipped with a healing pad, which you need to wrap around the affected area.As you switch on the machine, the water will begin to flow from the tank to the healing pad. The healing power of cold therapy will begin to show results from the very first session.Cold Therapy Unit – BenefitsEfficient delivery of cold therapy –One of the biggest benefits of using a cold therapy unit is the way it helps with efficient delivery of freezing temperatures.The cold temperature hinders nerve communication in the area of application. Lack of nerve communication temporarily stops the blood supply to the same area. The inflammation begins to go down due to reduced blood supply. As the inflammation reduces; it also results in lessening of the pain.But if the delivery of cold temperature is not optimal; it is not possible to generate the best results from its use. Using ice packs or frozen vegetable bags don’t offer the same benefits. Their uneven shape doesn’t allow the cold temperature to reach deep within the injured tissues.The healing pads in cold therapy units help the cold temperature reach the affected muscles properly. IsoComforter utilizes the patented Iso tube technology to make its cold therapy units. Use of this technology helps in the most efficient delivery of cold therapy. Such excellent delivery of cold therapy is necessary for patients to experience speedy pain relief.Safe delivery of cold therapy –There are no risks of infections when you use a cold therapy unit. Unlike ice packs, water doesn’t drip from the machines. So, you don’t need to worry about post-operative infections when you use the machine on incisions or open wounds. IsoComforter healing pads have ridges, which help in the safe delivery of cold temperature on the skin.Easy delivery of cold therapy –Using a cold therapy unit is easy and convenient. It helps the patients to continue with their cold therapy healing sessions until their recovery is complete. Consistency is important when it comes to benefiting fully from cold therapy.It is also easy to operate the machine. There are no hassles involved in it. When you use IsoComforter cold therapy units; you don’t even to need to replenish the water in the tank very often. You can sit back and relax while the machine delivers cold therapy to your injured muscles.